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our findings suggest that metformin could be a useful adjuvant agent, with the greatest benefits seen in colorectal and prostate cancer, particularly in those receiving radical radiotherapy, and randomised, controlled trials which investigate dose and duration, alongside efficacy, are advocated.

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metformin reduces tumor growth not only indirectly systemic effect glucose and insulin lowering but also by direct inhibition of energetic metabolism 18 and inhibition of pathways involved in cell proliferation 18 20 , through both ampk-dependent 21, 22 and -independent mechanisms 23 27 .

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